Intraoperative molecular imaging to identify lung adenocarcinomas

Intraoperative molecular imaging can identify lung adenocarcinomas during pulmonary resection.

BACKGROUND More than 80,000 people undergo resection of a pulmonary tumor each year, and the only method to determine if the tumor is malignant is histologic analysis. We propose that a targeted molecular contrast agent could bind lung adenocarcinomas, which could be identified using real-time optical imaging at the time of surgery. METHODS Fifty patients with a biopsy-proven lung adenocarcin...

Molecular regulation of S100P in human lung adenocarcinomas.

Lung adenocarcinoma is characterised by an upregulation of S100P, which mediates its function intracellularly but also extracellularly. Recent studies suggest that extracellular S100P contributes to tumour development following interaction with the receptor for advanced glycation end-products (RAGE). As RAGE is highly downregulated in lung cancer, one might speculate that S100P supports tumorig...

Magnetic Resonance Imaging to Identify Glioblastoma Molecular Phenotypes. - PubMed - NCBI

Bronchioloalveolar differentiation in lung adenocarcinomas.

The goals of the study were to determine what percentage of neoplasms with a bronchioloalveolar (BAC) component were considered pure BAC by current World Health Organization (WHO) criteria. Next, we wanted to determine the number of mucinous BACs using histochemical staining with Alcian Blue PAS. Finally, we aimed to elucidate by immunohistochemistry the thyroid transcription factor-1 (TTF-1) f...

Intraoperative Molecular Imaging for Rapid Assessment of Tumor Margins